Andrew Rotich

About Andrew Rotich

https://www.genbioconsortium.africa/

Posts by Andrew Rotich:

The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria

June 12, 2024

Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory responses across the immune landscape. These regulatory responses help to protect against inflammatory disease but may in some situations hamper the acquisition of adaptive immune responses that clear parasites. In addition, the regulatory responses that occur during Plasmodium infection may negatively affect malaria vaccine efficacy […]

Genetics of flight in spongy moths (Lymantria dispar ssp.): functionally integrated profiling of a complex invasive trait

June 4, 2024

Flight can drastically enhance dispersal capacity and is a key trait defining the potential of exotic insect species to spread and invade new habitats. The phytophagous European spongy moths (ESM, Lymantria dispar dispar) and Asian spongy moths (ASM; a multi–species group represented here by L. d. asiatica and L. d. japonica), are globally invasive species […]

Reagent-free detection of Plasmodium falciparum malaria infections in field-collected mosquitoes using mid-infrared spectroscopy and machine learning

May 30, 2024

Field-derived metrics are critical for effective control of malaria, particularly in sub-Saharan Africa where the disease kills over half a million people yearly. One key metric is entomological inoculation rate, a direct measure of transmission intensities, computed as a product of human biting rates and prevalence of Plasmodium sporozoites in mosquitoes. Unfortunately, current methods for […]

Upscaling irradiation protocols of Aedes albopictus pupae within an SIT program in Reunion Island

May 28, 2024

As part of the up-scaling process towards a SIT pilot trial against Ae. albopictus on La Reunion, the aim of the present study was to develop an efficient upscaled irradiation protocol for a weekly production of 300 000 sterile males of Ae. albopictus with the specificities of the only available irradiator on the island. Using […]

Spatio-temporal characterization of phenotypic resistance in malaria vector species

May 22, 2024

Malaria, a deadly disease caused by Plasmodium protozoa parasite and transmitted through bites of infected female Anopheles mosquitoes, remains a significant public health challenge in sub-Saharan Africa. Efforts to eliminate malaria have increasingly focused on vector control using insecticides. However, the emergence of insecticide resistance (IR) in malaria vectors pose a formidable obstacle, and the […]