Engineered gene drives share many environmental risk assessment considerations with other transgenes in genetically modified organisms, but they can differ significantly in their potential to spread, increase in frequency, and persist in target populations. Recently, introduction of mosquitoes with an engineered gene drive completely suppressed caged wild type laboratory populations of the malaria vector Anopheles gambiae, belonging to a species complex containing both vector and nonvector species that can produce fertile interspecific hybrids.
Connolly, J. B., Romeis, J., Devos, Y., Glandorf, D. C., Turner, G., & Coulibaly, M. B. (2022). Gene drive in species complexes: defining target organisms. Trends in Biotechnology.