Background DUYAO-JIEYAO encodes a toxin-antidote system that confers hybrid male sterility DUYAO interacts with OsCOX11 to trigger mitochondrial malfunction and cytotoxicity JIEYAO detoxifies DUYAO by rerouting DUYAO to the autophagosome for degradation DUYAO-JIEYAO forms a natural gene drive system that may promote speciation in rice Such a natural gene drive could be engineered to reduce […]
Background Malaria is among the world’s deadliest diseases, predominantly affecting Sub-Saharan Africa and killing over half a million people annually. Controlling the principal vector, the mosquito Anopheles gambiae, as well as other anophelines, is among the most effective methods to control disease spread. Here, we develop a genetic population suppression system termed Ifegenia (inherited female elimination […]
Background Novel genetic strategies for the malaria eradication agenda exploit Cas9/gRNA (guide RNA)-based autonomous gene-drive systems carrying antiparasite effector genes, and these effectively reduce prevalence and numbers of the human parasite, Plasmodium falciparum, in the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii. Results from laboratory assessments of population gene-drive dynamics, transgene genetic loads, and parasite suppression efficacy informed modeling […]
Background Wolbachia-based incompatible insect technique (IIT) and pathogen blocking technique (PBT) have been shown to be effective at protecting humans from mosquito-borne diseases in the past decades. Population suppression based on IIT and population replacement based on PBT have become major field application strategies that have continuously been improved by the translational research on Wolbachia-transinfected […]
Background For decades, techniques to control vector population with low environmental impact have been widely explored in both field and theoretical studies. The incompatible insect technique (IIT) using Wolbachia, based on cytoplasmic incompatibility, is a technique that Wolbachia-infected male mosquitoes are incapable of producing viable offspring after mating with wild-type female mosquitoes. Matsufuji, T., & Seirin-Lee, S. […]
Resources
The African Genetic Biocontrol Consortium. All Rights Reserved, © 2022
Privacy Policy
Terms of Service