Experimental demonstration of tethered gene drive systems for confined population modification or suppression
Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This could represent a substantial sociopolitical barrier to the testing or deployment of such drives and may generally be undesirable when the objective is only local population control, such as suppression of an invasive species outside of its native range.
Metzloff, M., Yang, E., Dhole, S., Clark, A. G., Messer, P. W., & Champer, J. (2022). Experimental demonstration of tethered gene drive systems for confined population modification or suppression. BMC biology, 20(1), 1-13.