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Genetic differentiation of Plasmodium vivax duffy binding protein in Ethiopia and comparison with other geographical isolates

February 29, 2024

Plasmodium vivax Duffy binding protein (PvDBP) is a merozoite surface protein located in the micronemes of P. vivax. The invasion of human reticulocytes by P. vivax merozoites depends on the parasite DBP binding domain engaging Duffy Antigen Receptor for Chemokine (DARC) on these red blood cells (RBCs). PvDBPII shows high genetic diversity which is a major challenge to its use in the development of a vaccine against vivax malaria.

Abebe, A., Dieng, C.C., Dugassa, S. et al. Genetic differentiation of Plasmodium vivax duffy binding protein in Ethiopia and comparison with other geographical isolates. Malar J 23, 55 (2024). https://doi.org/10.1186/s12936-024-04887-1