Background Engineered gene drives share many environmental risk assessment considerations with other transgenes in genetically modified organisms, but they can differ significantly in their potential to spread, increase in frequency, and persist in target populations. Recently, introduction of mosquitoes with an engineered gene drive completely suppressed caged wild type laboratory populations of the malaria vector Anopheles […]
Background Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight against malaria in sub-Saharan Africa. Leung, S., Windbichler, N., Wenger, E. A., Bever, C. A., & Selvaraj, P. (2022). Population […]
Background Gene drive mosquitoes are increasingly considered a potential transformational tool for vector control of malaria mosquitoes. As part of efforts to promote responsible research in this field, a number of guidance documents have been published by the World Health Organization, National Academies and expert groups. While virtually all recent guidance documents on gene drive […]
Background CRISPR-based gene drives offer novel solutions for controlling invasive alien species, which could ultimately extend eradication efforts to continental scales. Gene drives for suppressing invasive alien vertebrates are now under development. Using a landscape-scale individual-based model, we present the first estimates of times to eradication for long-lived alien mammals. We show that demography and […]
Background With the increasing burden of mosquito-borne diseases around the world and the traditional control methods showing drawbacks, the sterile insect technique (SIT) is now a potential new tool in the field of controlling mosquitoes. During the implementation of SIT, several steps, such as handling, transportation and release, are of great importance and stand a […]
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